
Kinisoquin™ acts on 13+ biomarkers. Highlights from Phase 2:
Phase 3
Lead program under FDA Special Protocol Assessment
Zero
Zero VTE and no major bleeding in Phase 2
−73%*
PDI (protein disulfide isomerase)
−22%*
D-Dimer
−58%*
sP-selectin
2045
Patent protection runway
*Statistically significant reduction in Phase 2
Harvard Medical School · Beth Israel Deaconess · National Institutes of Health · Memorial Sloan Kettering · ETH Zürich · Pasteur Institute
PIPELINE
A Phase 3 lead program, with a platform behind it
Oncology
VTE in Metastatic Pancreatic Cancer
Kinisoquin™ monotherapy · FDA Special Protocol Assessment
Phase 3
VTE in Ovarian Cancer
Kinisoquin™ monotherapy · with NIH and MSKCC
Phase 2/3
Cancer (All Solid Tumors) — RTT (Right to Try) and Expanded Access (EA)
Kinisoquin™ + Zafirlukast combination
Phase 2/3
Lung Cancer
Kinisoquin™ + Zafirlukast combination
Phase 2
Hematology / Thrombosis
Sickle Cell Disease
Kinisoquin™ monotherapy · steady state, crisis and transfusion dependent
Phase 3
Virally Induced Thrombosis
Kinisoquin™ monotherapy · incl. SARS-CoV-2 and Ebola
Planned
Virology
Measles, SARS-CoV-2, H1N1, H5N1 and Ebola
Kinisoquin™ + Zafirlukast combination
Phase 2/3
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